Symbol
Name
ID

Cxcr2
C-X-C motif chemokine receptor 2
MGI:105303

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Nephritis
Disease(s) Associated with CXCR2	Nephritis
IgA glomerulonephritis

Mouse Phenotypes

immune system phenotype

abnormal granulocyte differentiation

impaired neutrophil chemotaxis

decreased thymus weight

enlarged spleen

increased spleen weight

decreased immature B cell number

decreased pre-pro B cell number

abnormal myelopoiesis

myeloid hyperplasia

increased eosinophil cell number

increased neutrophil cell number

increased granulocyte number

increased CD103-positive CD11b-low dendritic cell number

decreased mature B cell number

decreased B cell number

decreased pre-B cell number

increased B cell number

increased memory-marker NK cell number

increased CD4-positive, alpha-beta memory T cell number

increased KLRG1+ CD4 alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta memory T cell number

increased KLRG1+ CD8 alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased memory-marker CD4-positive NK T cell number

increased effector memory T-helper cell number

increased memory-marker gamma-delta T cell number

increased gamma-delta T cell number

decreased T cell number

increased Ly6C high monocyte number

increased Ly6C low monocyte number

increased monocyte cell number

increased leukocyte cell number

decreased spleen weight

abnormal spleen white pulp morphology

abnormal leukocyte physiology

abnormal eosinophil physiology

abnormal neutrophil physiology

impaired neutrophil recruitment

increased IgE level

abnormal T cell physiology

abnormal T-helper 1 physiology

abnormal T-helper 2 physiology

abnormal NK T cell physiology

increased circulating interleukin-6 level

abnormal chemokine level

abnormal interleukin level

lymph node medullary cord hyperplasia

enlarged lymph nodes

enlarged cervical lymph nodes

abnormal cytokine secretion

decreased susceptibility to induced arthritis

increased anti-nuclear antigen antibody level

decreased susceptibility to bacterial infection induced morbidity/mortality

increased susceptibility to bacterial infection

decreased susceptibility to fungal infection

increased susceptibility to parasitic infection

increased susceptibility to Herpesvirales infection

Availability

Mouse Genotype

Cxcr2^{tm1(IL8RB)Dktr}/Cxcr2^{tm1(IL8RB)Dktr}

Cxcr2^{tm1a(EUCOMM)Wtsi}/Cxcr2^{tm1a(EUCOMM)Wtsi}

Cxcr2^tm1Mwm/Cxcr2^tm1Mwm

Cxcr2^tm1Mwm/Cxcr2⁺

Cxcr2^tm1Rmra/Cxcr2^tm1Rmra
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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